How Does Diazepam Work?

How Does Diazepam Work?

The occurrence of anxiety and seizures results from lessened or a slower function of the brain chemical, named gamma-aminobutyric acid, also known as GABA. This chemical is responsible for transmitting messages across all nerves in the body, resulting in the balance of the central nervous system. The process assists in memory retention, epilepsy avoidance, decreased anxiety and sleep induction.

Like all benzodiazepines, diazepam tablets can increase the activity of this brain chemical. GABA reduces unusual nerve excitement in the CNS, commonly the main reason for anxiety and insomnia. In essence, the tablet can decrease hyperactivity in the brain.

When the tablet is ingested, it is broken down and converted into its active metabolites. Its allosteric attachment to GABA-A receptors is mainly responsible for its anti-anxiety effects. This attachment in the spinal cord and motor neurons is a primary contributor to the tablet's muscle-relaxant properties.

The tablet appears to act on numerous brain regions, therefore having various properties. Valium acts on the thalamus, which is responsible for motivation, memory, emotion and consciousness. It also affects the hypothalamus, which is responsible for sleep-wake cycles, fatigue and regulating body temperature. Patients commonly use diazepam for insomnia that may be related to anxiety.

Additionally, this treatment's anticonvulsant property is due to its ability to regulate sodium levels within the nerve cells in conjunction with decreasing excess electrical activity in the brain. The inhibition of chemical pathways within the spinal cord gives the medication its muscle-relaxant properties.

How Long Does Diazepam Take to Work?

Due to this treatment's long half-life duration of more than 12 hours, it is considered a long-acting benzodiazepine. When ingested, the substance remains in the patients' system for a more extended amount of time compared to other benzodiazepine anxiety medication. This characteristic allows patients to efficiently use the tablet short term and enables a more comfortable dosage reduction period when needed.

When diazepam is taken on an empty stomach, the effects should be felt within 30 minutes to 1 hour. For a quicker response time, patients would have to take the tablet sublingually. By letting it dissolve under the tongue, it is faster than swallowing.

Individuals experience the medication differently, nevertheless it maintains its intended effects with high efficacy to treat the applicable condition at hand. It can also elevate patients' mood and improve sleep quality without negatively altering the architecture of sleep.

Diazepam Help You Sleep

Does Diazepam Help You Sleep?

Common effects of benzodiazepine medications are reduced anxiety, muscle relaxation and increased sleepiness. Valium 10 mg is no different, as it can improve sleep quality and duration. Although this is an off-label use, many patient reviews clearly show the medication's effectiveness in treating sleep difficulties such as insomnia.

Sleep is important in maintaining optimal health and a high standard of living. It plays an important role in the upkeep of the body, such as repairing blood vessels and reducing stress. Sleep is also an important factor when treating conditions, such as anxiety and depression.

Insomnia affects at least 10% of the population. It is important for patients to address this condition, as it can affect other aspects of life. This includes anxiety levels and other medical conditions that they may have. Typically, decreased GABA activity is said to be the cause of insomnia and other sleep issues.

There are many prescription sleeping medications on the market and this can make the patient feel overwhelmed. This is where the use of this approved therapeutic comes in. This medication is an effective anxiolytic, but enhancing GABA facilitates sleep initiation and maintenance as well. Increased GABA allows the mind and body to relax and initiate quality sleep, and maintain this sleep throughout the night.

This medication is perfect for sleep issues as it acts on multiple brain receptors to initiate sleep without interfering with normal functions of the body. Patients will receive a full 8 to 9 hours of sleep, due to its longer lasting and residual effects in the body.

Does Diazepam Help Depression?

Depression is broadly a group of conditions which decrease one's mood and general interests in hobbies, socialising and other daily or essential activities. It is commonly associated with lack of sleep and anxiety disorders. If depression is ignored, it can interfere with every part of everyday life, so it is imperative not to leave it untreated.

Depression can also cause physical health problems, such as diabetes, heart disease and other chronic conditions. This mental illness can also accelerate the progression of certain diseases. However, there is a solution in pharmaceuticals like this treatment. Since it is known to significantly decrease symptoms of anxiety, relax muscles and facilitate sleep, it is often used for depression or where depression is a secondary condition.

These therapeutic effects are beneficial in the treatment of depression that may be related to insomnia or anxiety. In a study conducted by medical experts, J W Tiller and others, this medication was compared with an antidepressant called moclobemide. The patients had atypical depression and were give these medications.

Both agents improved the symptoms of depression, but this treatment was found to be a considerably better antidepressant than moclobemide. After eight weeks, when the study concluded, patients did not have severe withdrawal reactions upon discontinuing the medication. Following the study, diazepam for depression has been a common purchase and is more frequently recommended by experts.

Diazepam for Flying

Many individuals experience anxiety and nervousness in the event of flying, as the turbulence, crowded spaces and the feeling of taking off and landing can overwhelm them. This is normal, but certain individuals experience extreme fear when flying and hence avoid the activity altogether. This aversion is known as aerophobia.

Getting onto a plane may trigger panic attacks and other physical symptoms of anxiety, including:

  • Trembling
  • Nausea
  • Increased heart rate
  • Shortness of breath

This pharmaceutical is an anti-anxiety medication used to treat anxiety disorders and reduce its symptoms. Therefore, patients can comfortably use diazepam for flying. Taking a 2 mg tablet before boarding a flight can help anxious fliers calm down and reduce the occurrence of panic attacks.

It can also take the edge off the unwanted sensations of landing and taking off. The medication can further aid in better sleeping, allowing patients to get an adequate amount of rest on flight. Patients should remember that they should not consume alcohol or caffeine-containing products if they have taken this medication before their flight.

For more information see our other articles below or visit our online pharmacy now.

Updated: 15th January 2021
Review Due: January 2022



Fueled with a passion to try and help people less fortunate than himself Steve immersed himself in the medical industry. By researching new and innovative medical advancements and regularly sharing important information on social media Steve intends to make a difference where it matters most, people's health. His wealth of knowledge and keen eye for detail will help keep our readers informed and contribute towards improved health.

Kirsten Smith – Feb 26, 2021
Dear Steve, I found your well written article most informative. I suffer from occasional bouts of anxiety which is heightened when I travel. I recently landed my dream job but it had one drawback, frequent long-haul flying. Having read this piece, I decided to try Diazepam and was delighted with the results. My anxiety and nervousness were gone and I managed to sleep for pretty much the entirety of the flight (8 hours). I woke up feeling great and was able to perform at my best when it mattered. Thank you. Kirsten Smith

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