Is Zopiclone the Same as Zolpidem?

Is Zopiclone the Same as Zolpidem?

These medications are not the same. They are both classified as non-benzodiazepines, and they are both sleeping pills, but differ slightly in chemical structure. Non-benzodiazepines are similar to benzodiazepines with regard to the mode of action, the adverse events and the risks associated with use. However, these two classes of medications are different at the molecular level which owe to the differences of their safety and tolerance.

Non-benzodiazepines are colloquially referred to as "Z-drugs" because of the starting letter of the pharmaceutical names. They are used for similar purposes, which includes their primary function as a sleeping aid for those experiencing acute or chronic insomnia. These sleeping pills are not only for those experiencing sleep maintenance issues but also for those who have a problem with sleep initiation.

In all, non-benzodiazepines have been proven to be safer and better tolerated than benzodiazepines. Even though both these classes of medications potentiated GABA activity, the newer non-benzodiazepines produce less addiction and are more selective as well. Zopiclone and other "Z-drugs" were originally marketed to be alternatives to benzodiazepines.

Both zopiclone 7.5 mg tablets and zolpidem 10 mg tablets are sedatives and depress or tranquilize the central nervous system (CNS). However, zopiclone is categorised as a cyclopyrrolone whilst the latter is an imidazopyridine.

Studies by Nakajima et al. (2000) suggested that the profiles of action of these two compounds, relating to the two major subunits of the GABAA receptor, differ (GABA, gamma-amino butyric acid, is the main inhibitory neurotransmitter found in the CNS).

The possibilities of developing tolerance to these sleep medications restricts their use to the short-term only. Zopiclone is normally used for a week or two as compared to its counterpart sedative which can be used for up to four weeks.

Zopiclone vs Zolpidem

Both these sleep medicines were part of the first "Z-drugs" to be marketed. They generally exhibit similar efficacy in terms of their use as sleep aids but there have been differences in the side effects experienced with these medications.

In a double-blind, comparative study of these hypnotic medicines, 479 chronic primary insomniacs were evaluated for their response to these sleeping pills. Tsutsui et al. (2001) found that the improvements to sleep latency were more significant for zolpidem users than zopiclone 7.5 mg (85.8% versus 77.5%) and there were also fewer adverse events related to the use of the aforementioned sleep aid (31.3% versus 45.3%).

The study concluded that both these medicines were as effective as the other, but zopiclone was found to be less well-tolerated than zolpidem tablets and was associated with more rebound insomnia cases. This can still vary from person to person, depending on individual preference and tolerance.

Is Ambien the Same as Zolpidem?

Ambien is the trade name under which this sedative is marketed in the United States and most of Europe. Other brand names differ in certain parts of the world. For example, in France, this sleep medication is commonly known as Stilnox.

Different brands can work differently depending on their compositions. One of the common differences includes the rate at which the active ingredient in the tablets or capsules is dissolved. This will affect the absorption rate and hence, the therapeutic effects of the medication.

Brands tend to be more expensive than the average generic medications. In fact, they can cost approximately 80 to 85% more than their generic counterpart. This is in part due to the expired patent of the branded medication and the generic manufacturer does not have to invest the capital into the invention or patenting of the medicine.

The generic version of the brand, Ambien, is named after the active ingredient of the sleeping pill. They are both used for the same purpose - as sedatives - but differ in their costing and packaging etc.

Benefits of Zolpidem (Ambien)

Ambien is primarily used to help insomnia sufferers sleep better. There are different formulations which promote different aspects of sleep. The immediate-release Ambien tablets are known for their fast action. These tablets release the active ingredient quickly and the therapeutic benefits can be observed with half an ago of administration. This sleeping pill is ideal for those who have trouble falling asleep.

For those who have difficulty staying asleep, in other words, if waking up too early is an issue, Ambien CR can be an effective solution. Ambien CR is an extended-release form of the sleep aid and the effects can last longer than the fast-acting form. The main ingredient is slowly released in the body over a period of time and allows for longer lasting sedation throughout the night.

There are also sublingual tablets of zolpidem which are lower dosages of the sedative ingredient and can be used for middle-of-the-night awakenings. These tablets are available in generic versions as well.

Other mild therapeutic actions of this sleep aid involves its anticonvulsant, muscle relaxant and anxioloytic properties.

Benefits of Ordering Zolpidem

Benefits of Ordering Zolpidem Online

Digital shopping has fast become the most preferred way to buy medications, like zolpidem online and this is due to various reasons:

Convenience: instead of shopping the traditional way; time, energy and money can be saved by shopping online. Online pharmaceutical retailers have arranged for the needs of consumers to be met with regard to the medication they require. You can now find any type of medication you need (be it a branded or generic version), gain insight on the side effects and therapeutic benefits of the medications and view all the ingredients of the healthcare products before you buy sleeping tablets online.

Where else can you buy a healthcare product at midnight when you are most comfortable?

Cost-effectiveness: apart from saving the cost of physically going into a store, there are additional discounts and promotions which can be found online only. Buying online also has the added advantage of a wider range of products than what is typically displayed in a retail store.

The main advantage of shopping online is that it allows you the opportunity to lower your monthly expenses.

Consumer protection: As a reputable supplier, we protect the information of our consumers. This gives you the peace of mind that you will not be misled in any way. We have a proper description of the products we offer and allow you sufficient time to make an informed decision.

We protect our consumer's rights and abide by the terms and agreements as listed on our website.

Updated: 14th January 2021
Review Due: January 2022



Fueled with a passion to try and help people less fortunate than himself Steve immersed himself in the medical industry. By researching new and innovative medical advancements and regularly sharing important information on social media Steve intends to make a difference where it matters most, people's health. His wealth of knowledge and keen eye for detail will help keep our readers informed and contribute towards improved health.

David West – Mar 14, 2021
Hello Steve, I owe you a big thank you. Your wealth of knowledge and this blog is particular has been a great source of information and tremendous benefit to me. David West

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