Painkiller Side Effects

Painkiller Side Effects

Pain is an uncomfortable sensation generated by the nervous system due to various ailments, tissue damage or other injuries to the body. It can occur as a specific feeling in one part of the body or a widespread sensation that cannot be pinpointed.

The experience of pain is invariably connected to psychological, emotional, and cognitive factors that can wreak havoc in an individual's life if left untreated. Thus, most patients choose treatment rather than ignorance. Painkillers are the most effective pain solution as they are made of chemical compounds that band together to target and eliminate individual pain sensations.

As with any medication, the benefits of these tablets come with the possibility of side effects. Painkiller side effects differ in intensity and severity; thus, most treatment manufacturers break them up into three categories, namely common, uncommon and rare side effects. Mild side effects typically do not require medical interventions such as a doctor's visit because they are short-lived and manageable.

On the other hand, rare and severe side effects are unbearable and long-lasting. The occurrence of these side effects most often indicates a complication like an allergic reaction or contraindication. Painkillers have a comprehensive list of side effects included in their PIL, which patients must acknowledge before starting their treatment.

Common Painkiller Side Effects

Painkillers produce a wide range of beneficial effects that outweigh the risk of possible side effects; however, most individuals are still discouraged by them. Patients are urged not to let the possibility of side effects rule out the use of a painkiller, especially if it can manage pain successfully.

Jim Owen, vice president of practice and science affairs at the American Pharmacists Association, said "Side effects can happen with almost any medicine. They're common with everything from birth control pills to cancer-fighting chemotherapy drugs."

Thus, patients should not be deterred by common painkiller side effects like:

This symptom can be lessened and eventually eliminated with an increased intake of water or dietary fibre if the patient's condition permits it. Alternatively, they can opt for moderate exercise, approved laxatives or stool softeners.

Nausea or vomiting frequently occur in the first day or two of taking any pain management treatment. Patients can easily overcome this symptom by taking anti-nausea tablets.

Drowsiness following painkiller use is typical and often lasts just a day or two; however, some patients find that the symptom reoccurs following dosage increases. To minimise this symptom, patients should have small naps if possible until the feeling has passed or try engaging in light activity to eliminate the feeling. Energy bars are also quite useful in this instance.

These side effects frequently occur at the beginning of treatment plans as the body becomes accustomed to it. Once the body becomes familiar with the treatment and its effect, the side effects gradually decrease in intensity before completely disappearing.

Experts encourage patients not to prematurely discontinue their treatment at first sight of a common side effect. Instead, they should continue taking their prescribed doses while treating the side effects with the remedies mentioned above.

Uncommon Painkiller Side Effects

According to statistics, uncommon side effects affect 1 in 1000 people. These side effects usually have a mild to moderate expression. Patients who experience these effects are urged to note each effect's duration and severity for consultation with a medical practitioner. Once the cause of the side effect is identified, patients will be advised of the best way forward.

Uncommon painkiller side effects include:

  • Migraine headaches, mild skin rashes
  • Euphoria, over excitement, chills, confusion
  • Anxious feelings, vision changes, ringing in the ears
  • Decreased appetite, diarrhoea
  • Difficult or painful urination, inability to completely empty the bladder
  • Difficulty sleeping, nightmares excessive sweating, fast heartbeat
  • Heart throbbing or pounding
  • Skin sensitivity, hives, erythema, skin redness
  • Intense abdominal pain, constipation or bloating
  • Loss of muscle coordination, muscle tremors
  • Throat, nose or mouth dryness, trouble breathing, wheezing, chest discomfort
  • Malaise, low energy

Jim Owen added that there are many factors that influence side effects, besides the medication itself, and one may be able to avoid them by staying away from alcohol or certain foods, or by applying dietary and lifestyle changes.

If lifestyle changes do not help combat these symptoms, most professionals call for a decrease in dose.

Painkiller Side Effects

Rare Painkiller Side Effects

Rare side effects usually have a severe expression, because they are often a sign of complication or underlying condition. These complications include allergic reactions to the painkiller or its ingredients, severe treatment/medical condition interactions or contraindications and overdosing.

Rare painkiller side effects include:

  • Blood disorder
  • Blood disorders like haemolytic anaemia
  • Acute liver failure or liver damage and inflammation
  • Decreased blood platelets
  • Extra heartbeats
  • Hallucinations
  • Low blood pressure
  • Anaphylaxis or angioedema
  • Low levels of white blood cells
  • Seizures
  • Vocal cord swelling
  • Skin disorders

These painkiller side effects can also occur when patients completely ignore dosage and usage guidelines and take the medication under ill-advised circumstances. The occurrence of any one of these side effects requires an emergency doctor’s or hospital visit, and the use of the medication should be immediately discontinued.

Painkiller Effects Explained

Pain is identified broadly as complicated feelings of discomfort that are unique to each person, their circumstances and mood. Thus, painkillers are not designed with a one size fits all structure. Painkillers often work with different biological mechanisms - some stop tissue swelling while others alter the body's standard pain thresholds. Although each of these solutions has a different mechanism of action, all painkiller side effects remain roughly the same.

NSAID's such as ibuprofen and aspirin, produce their pain relief effects by changing how the body responds to pain as well as swelling. Milder opiate painkillers like codeine, on the other hand, function by modifying the way pain signal is transmitted in the brain and spinal cord, while others block pain signals entirely. Some pain solutions or treatment plans can also contain multiple painkillers - for example, aspirin or paracetamol can be added to codeine for greater efficacy.

These painkiller hybrids are usually prescribed to patients with intense or chronic pain. The consumption of several painkillers in certain situations are usually prescribed to manage such pain more efficiently. However, patients should be cautious when consuming more than one painkiller as complete adherence to guidelines, dosage and frequency is vital for safe, successful treatment results.

For more information on how to buy painkillers from our website (such as Tramadol 50 mg tablets & Pregabalin 300 mg tablets), the customer service team at is available to help 24-hours.

You may also find the information you are looking for in the related articles below.

Updated: 27th January 2021
Review Due: January 2022



Fueled with a passion to try and help people less fortunate than himself Steve immersed himself in the medical industry. By researching new and innovative medical advancements and regularly sharing important information on social media Steve intends to make a difference where it matters most, people's health. His wealth of knowledge and keen eye for detail will help keep our readers informed and contribute towards improved health.

Charles Thomas – Mar 01, 2021
Hello Steve, your blog on pain killers and their side effects has been a real eye opener and I have found it most beneficial. I suffer from chronic back pain and have been reluctant to take strong painkillers due to the various side effects. Your well written article has answered so many of my questions and has now given me the confidence and knowledge to manage my pain better. Thank you very much. Charles Thomas

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