Which Painkiller is Best?

Which Painkiller is Best?

When we think of the best painkiller, several names come to mind. This is because painkillers are structured and designed with unique identities that accommodate different pain types and levels. Thus, one specific solution cannot be chosen for all circumstances.

The choice of the ideal pain reliever often depends on various internal and external factors. The WHO analgesic ladder of medicines is an excellent tool, which often helps patients identify their pain and investigate possible treatment options.

Below is a summary of commonly used pain relievers:

Best Painkiller Options Key points
Paracetamol Paracetamol can be administered to treat mild to moderate pain.
  • It acts primarily on the brain and affects how the user feels pain.
  • It has an exceptional safety profile and a versatile disposition that allows it to treat both acute and chronic pain.
  • It is ideally used when needed; however, it should be taken at regular intervals for chronic pain.
Non-steroidal anti-inflammatories
  • Ibuprofen
  • Diclofenac
  • Naproxen
  • Mefenamic acid
NSAIDs are used to treat mild-to-moderate inflammation or swelling and pain
  • They function by inhibiting and reducing hormones and enzymes that cause swelling and pain within the body.
  • NSAIDs can be administered for short-term pain resulting from injuries or due to flare-up.
  • NSAIDs may not be ideal for longer-term pain issues as they treat cases of inflammation, which are usually not the cause of chronic pain.
Opioids Opioids can be administered to treat moderate-to-severe temporal pain that stems from various conditions or injuries. In certain situations, they can be used long term as well.
  • Codeine, tramadol and dihydrocodeine are typically prescribed for moderate pain, while oxycodone and morphine are administered for more extreme or severe pain levels.

  • Gabapentin and pregabalin can be taken to treat specific types of pain only. One of them includes nerve pain.
  • Gabapentin must be taken daily, to work effectively.
  • Successful full-scale pain relief can be felt in 3 to 6 weeks.
  • The tablet can be taken as long as it is needed.

Best Painkiller for Period Pain

Menstruation, commonly known as a period, is a monthly cycle of vaginal bleeding that occurs in all adolescent women. This bleeding is often accompanied by varying levels of pain called dysmenorrhea. This pain is sometimes unbearable, and women often look to painkillers to help alleviate their symptoms.

According to the ACOG (American College of Obstetricians and Gynaecologists), NSAID is the best painkiller option for menstrual cramps. Some studies even found that these drugs could decrease abnormally heavy flows or bleeding.

Anti-inflammatory painkillers are often used to relieve menstrual pain because they inhibit the production of prostaglandins. Prostaglandins are a group of compounds with varying-like effects, which include the promotion of uterine contractions.

By blocking the production of this compound, the tablet successfully reduces period pain. NSAIDs are also the safer option, as they are not processed through the liver like most period pain medicines - instead, they are metabolised by the kidney, which ultimately safeguards the liver.

Best Painkiller for Toothache

Toothaches are often unpredictable as they can sometimes suddenly appear with no prior warning signs. A toothache can physically affect the body, causing excruciating pain, alarming facial swelling, and flu-like symptoms. The best way to manage a toothache is to understand what causes it.

Over the years, dental experts have pinpointed the origin of toothaches to be internal swelling. The pulp (blood vessels, nerve and connective tissues) becomes too large for the tooth's rigid and inflexible structure, leaving no space for expansion and pressure reduction. The key to getting rid of the pressure is to stop and reduce the inflammation with painkillers, which are specifically designed to do so.

The most appropriate OTC option would be ibuprofen or aspirin, while the best painkiller in the prescription category would be codeine or co-codamol. These options are most effective because they can reduce swelling while simultaneously providing pain relief. These medications also come in combined treatment options, which can be purchased from any reputable online pharmacy.

Best Painkiller for Back Pain

Best Painkiller for Back Pain

Back pain is caused by several issues, from declining muscle mass or an injury to ailments like osteoarthritis. This type of pain is often lingering and can last a few weeks, months or even years. This means that it sits on the fence of acute and chronic pain. Due to this pain's ‘indecisive' nature, patients are urged to get relief as soon as possible.

Before patients choose the best painkiller for back pain, they must ensure that various factors of their pain and health are taken into consideration. The most common go-to treatment for back pain relief is NSAIDs. These pills are available OTC, however, patients who need higher doses require a prescription. NSAIDs can successfully reduce pain, swelling and inflammation in the muscles around damaged nerves, tissues, or joints causing the pain.
If patients find that this option is not providing sufficient relief, they might benefit from stronger treatment options like opioid analgesics. Opioids interact directly with brain receptors and the spinal cord to alter an individual's perception of pain. This process ultimately reduces intense pain sensations.

Best Painkiller for Headache

A headache is often described as mild to severe pressure experienced at the forehead's temples extending down to the neck's base. The unpleasant occurrence of a headache can leave a patient unable to function optimally; thus, treatment is vital. When headaches progress in severity, patients cannot treat them using traditional methods - this warrants the use of a good painkiller. The best painkiller for headaches includes both OTC and prescription medication options.

  • Over-the-counter painkillers - Simple OTC medications are usually the first line of treatment for headaches. Medications such as aspirin, ibuprofen and naproxen, among others, can provide effective relief to patients suffering from mild headaches.
  • Prescription painkillers- To alleviate severe tension-based headaches and migraines, prescription analgesics like opioid-based treatments are prescribed. These medications provide rapid pain relief within the prescribed timeframes.

Patients who do not find adequate relief with these options are often prescribed a fixed-dose combination treatment option. This option includes a single opioid painkiller paired with an over-the-counter treatment. Both treatment options will be prescribed at a standard dose that must neither be increased nor decreased. These combinations produce a higher level of relief and are commonly recommended to patients who suffer from severe/debilitating headaches.

For more information on how to buy painkillers, the customer service team at https://www.sleepingpillsuk.net/ is available to help 24-hours.
You may also find the information you are looking for in the related articles below.

Updated: 27th January 2021
Review Due: January 2022



Fueled with a passion to try and help people less fortunate than himself Steve immersed himself in the medical industry. By researching new and innovative medical advancements and regularly sharing important information on social media Steve intends to make a difference where it matters most, people's health. His wealth of knowledge and keen eye for detail will help keep our readers informed and contribute towards improved health.

Jane Fenwick – Mar 14, 2021
Hello Steve, Your article on painkillers is exceptional. The level of detail that you have provided has allowed me to make an informed choice and undoubtedly aided my recovery. Jane Fenwick

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